ABSTRACT
Background: A critical step in periodontal regenerative therapy is to alter the periodontitis affected root surface to make it a hospitable substrate, to support and encourage migration, attachment, proliferation and proper phenotypic expression of periodontal connective tissue progenitor cells. So the Concept of Biochemical modification or alteration of the root surface has emerged as a potential therapeutic approach to the reconstruction of the periodontal unit. Aim: To review various agents used for root biomodification and update on the current status of root biomodification in periodontal regenerative therapy. Materials and Methods: Google Scholar database is searched using keyword “Root Biomodfication”and the studies with experimental design either In Vivo or In vitro were included in the search whereas Narrative reviews or Non – Systematic reviews were excluded. These studies were reviewed together to update the various agents used for root biomodification and their current status in Periodontal regenerative therapy. Result: Only the representative studies of the agents used were included in this studies including 2 systematic review, 1 literature review and 1 world workshop report. Conclusion: The present status suggests that root biomodification does not have any added advantage in periodontal regeneration. Large Size randomized clinical trials are necessary to give an definite conclusion.
ABSTRACT
Gingival recession is defi ned as the apical migration of gingival margin to the cementoenamel junction. It results in root exposure which leads to clinical problems such as root surface hypersensitivity, root caries, cervical root abrasions, diffi cult plaque control, and diminished aesthetic/cosmetic appeal. Guided tissue regeneration based root coverage has emerged as a promising treatment modality. A variety of non-resorbable and bioresorbable membranes have been successfully used. Among resorbable membranes, collagen has been extensively studied. Recently, amnion membrane, the third generation membrane which is a placental derived tissue has been introduced. On the basis of the fi ndings of the present case report, it can be concluded that recently introduced amnion membrane (third generation membrane) are equally effi cacious in the treatment of gingival recession and use of this resorbable membranes with coronally advanced fl ap is a versatile treatment modality for root coverage of isolated buccal gingival recessions. Th e more gingival tissue thickness (gingival biotype) enhancement was observed with this membrane. Amnion membrane has certain additive advantages over the collagen membrane such as better handling properties and a thin diameter enabling it to mold according to the defect anatomy and root surfaces easily.